Structure of PDB 4x6k Chain A

Receptor sequence

>4x6kA (length=485) Species: 1073375 (Mediterraneibacter gnavus CC55_001C)

ADISNIFYAGDATKSNYFRIPSLLALDSGTVIAAADARYGGTHDAKSKIN
TAFAKSTDGGKTWGQPTLPLKFDDYVAKNIDWPRDSVGKNVQIQGSASYI
DPVLLEDKETHRVFLFADMMPAGIGSSNASVGSGFKEVDGKKYLKLHWKD
DAAGTYDYSVRENGTIYNDTTNSATEYSVDGEYNLYKNGNAMLCKQYDYN
FEGTKLLETQTDTDVNMNVFYKDADFKVFPTTYLAMKYSDDEGETWSDLQ
IVSTFKPEESKFLVLGPGVGKQIANGEHAGRLIVPLYSKSSAELGFMYSD
DHGNNWTYVEADQNTGGATAEAQIVEMPDGSLKTYLRTGSGYIAQVMSTD
GGETWSERVPLTEIATTGYGTQLSVINYSQPVDGKPAILLSAPNATNGRK
NGKIWIGLISETGNSGKDKYSVDWKYCYSVDTPQMGYSYSCLTELPDGEI
GLLYEKYDSWSRNELHLKNILKYERFNIDELKVQP

3D structure

• PDB: 4x6k Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation.
• Chain: A
• Resolution: 1.94 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3XR	A	R257 D282 I338 D339 R575 R637 Y677	R19 D44 I100 D101 R337 R399 Y439	MOAD: ic50=0.00487mM PDBbind-CN: -logKd/Ki=5.31,IC50=4.87uM

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Nov 24 19:51:45 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '4x6k', asym_id = 'A', title = 'Discovery of intramolecular trans-sialidases in ... suggests novel mechanisms of mucosal adaptation.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='4x6k', asym_id='A', title='Discovery of intramolecular trans-sialidases in ... suggests novel mechanisms of mucosal adaptation.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0004308', uniprot = '', pdbid = '4x6k', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0004308', uniprot='', pdbid='4x6k', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>