Structure of PDB 4x5y Chain A

Receptor sequence
>4x5yA (length=467) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINS
SAIKLQLTAQSQVQMKK
3D structure
PDB4x5y Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo.
ChainA
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3XW A S155 L177 S178 H181 F238 Y276 M278 M322 Y323 E363 E366 S134 L156 S157 H160 F217 Y255 M257 M301 Y302 E342 E345 MOAD: Kd=9.3nM
PDBbind-CN: -logKd/Ki=8.03,Kd=9.3nM
BindingDB: IC50=15nM,Kd=10.0nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4x5y, PDBe:4x5y, PDBj:4x5y
PDBsum4x5y
PubMed25817203
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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