Structure of PDB 4x41 Chain A

Receptor sequence
>4x41A (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
GIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAG
AKKVFGIECSSISDYSQKIIKANHLDNIITIFKGKVEEVELPVEKVDIII
SEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKD
FKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTV
KTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYT
HWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLC
ETSVSNDYKMR
3D structure
PDB4x41 Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity
ChainA
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D92 E185 E194 H334
Catalytic site (residue number reindexed from 1) D9 E102 E111 H251
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A H86 M89 R95 G119 G121 T122 I124 L125 E141 C142 K168 V169 E185 M196 H3 M6 R12 G36 G38 T39 I41 L42 E58 C59 K85 V86 E102 M113
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4x41, PDBe:4x41, PDBj:4x41
PDBsum4x41
PubMed26529540
UniProtQ9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 8 (Gene Name=PRMT8)

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