Structure of PDB 4x3j Chain A

Receptor sequence
>4x3jA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
VLKARMDAAIKELEVLCKLGHHPNIINLLLYLAIEYAPHGNLLDFLRKSR
VLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRNLAAR
NILVGENYVAKIADFGLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS
LGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERP
SFAQILVSLNRMLEERKTYVNTTLYEKFTYAGID
3D structure
PDB4x3j Selection of fragments for kinase inhibitor design: decoration is key.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N964 A966 R968 N969 D982
Catalytic site (residue number reindexed from 1) N96 A98 R100 N101 D114
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3WR A A853 E872 V875 I886 I902 Y904 A905 H962 L971 A981 D982 F983 A9 E12 V15 I26 I34 Y36 A37 H94 L103 A113 D114 F115
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4x3j, PDBe:4x3j, PDBj:4x3j
PDBsum4x3j
PubMed25437144
UniProtQ02763|TIE2_HUMAN Angiopoietin-1 receptor (Gene Name=TEK)

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