Structure of PDB 4x3g Chain A

Receptor sequence
>4x3gA (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPASCKWQGSL
DAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFML
VLEKQEKYQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIH
EGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4x3g Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L158 I163 V164 F165 L166 T168 D177 W178 V179 M180 L67 I72 V73 F74 L75 T77 D86 W87 V88 M89
BS02 ZN A C128 C135 H147 H152 C38 C44 H56 H61
BS03 ZN A C98 C105 H117 C121 C8 C15 H27 C31
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:4x3g, PDBe:4x3g, PDBj:4x3g
PDBsum4x3g
PubMed
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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