Structure of PDB 4x24 Chain A

Receptor sequence
>4x24A (length=237) Species: 345073 (Vibrio cholerae O395) [Search protein sequence]
MKIGIIGAMQQEVAILKDLIEDVQEVNQAGCTFYSGQIQGVDVVLLQSGI
GKVSAALGTALLISQYAPDVVINTGSAGGFDASLNVGDVVISSEVRHHDA
DVTAFGYEIGQMPGQPAAFKADEKLMTVAEQALAQLPNTHAVRGLICTGD
AFICTAEGQQFIRQHFPSVVAVEMEASAIAQTCHQFKVPFVVVRAISDVA
DKESPLSFEEFLPLAAKSSSAMVLKMVELLKENLYFQ
3D structure
PDB4x24 Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
ChainA
Resolution1.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.2.9: adenosylhomocysteine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TDI A M9 I50 S76 A77 G78 F152 I153 E173 M174 E175 D198 F208 M9 I50 S76 A77 G78 F152 I153 E173 M174 E175 D198 F208 MOAD: Ki=166pM
PDBbind-CN: -logKd/Ki=9.78,Ki=166pM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008782 adenosylhomocysteine nucleosidase activity
GO:0008930 methylthioadenosine nucleosidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0009086 methionine biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0019284 L-methionine salvage from S-adenosylmethionine
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4x24, PDBe:4x24, PDBj:4x24
PDBsum4x24
PubMed25806409
UniProtA5F5R2|MTNN_VIBC3 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (Gene Name=mtnN)

[Back to BioLiP]