Structure of PDB 4x1g Chain A

Receptor sequence
>4x1gA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRKD
LCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGII
SFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLS
YCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPG
VLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINA
QHTQRLLRIQDIHPFATPLMQELFGITGS
3D structure
PDB4x1g Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3WF A D205 L206 S247 F251 H407 R410 M425 D50 L51 S92 F96 H252 R255 M270 MOAD: Kd=11.5uM
BS02 3WG A M243 F281 Q285 F288 W299 Y306 M323 M88 F126 Q130 F133 W144 Y151 M168 MOAD: Ki=3.01uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4x1g, PDBe:4x1g, PDBj:4x1g
PDBsum4x1g
PubMed26333997
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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