Structure of PDB 4x1f Chain A

Receptor sequence
>4x1fA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVEAAKWSQVRKDLCS
LKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFA
KVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCL
EDQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVD
QLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLR
IQDIHPFATPLMQELFGITGS
3D structure
PDB4x1f Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3WF A D205 L206 M243 S247 F251 H407 R410 M425 D47 L48 M85 S89 F93 H244 R247 M262 MOAD: Kd=10.8nM
PDBbind-CN: -logKd/Ki=7.97,Kd=10.8nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4x1f, PDBe:4x1f, PDBj:4x1f
PDBsum4x1f
PubMed26333997
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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