Structure of PDB 4wzq Chain A

Receptor sequence

>4wzqA (length=476) Species: 12110 (Foot-and-mouth disease virus)

GLIVDTRDVEERVHVMRKTELAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH

3D structure

• PDB: 4wzq Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	E20 L108 D109 R128 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 S304 Y336	E20 L108 D109 R128 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 S304 Y336
BS02	rna	A	D114 F134 Y336 D338 D339 L386 K387 I411 R416 T419 E422 K423 S426 L430	D114 F134 Y336 D338 D339 L386 K387 I411 R416 T419 E422 K423 S426 L430
BS03	MN	A	D238 D339	D238 D339

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4wzq, PDBe:4wzq, PDBj:4wzq
• PDBsum: 4wzq
• PubMed: 25903341
• UniProt: P03311|POLG_FMDVS Genome polyprotein