Structure of PDB 4wzm Chain A

Receptor sequence

>4wzmA (length=475) Species: 12120 (Foot-and-mouth disease virus (strain C1-Santa Pau))

GLIVDTRDVEERVHVMRETKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAAALE

3D structure

• PDB: 4wzm Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
• Chain: A
• Resolution: 2.52 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	M16 E18 K20 L108 D109 T115 A116 R128 F162 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 Y336	M16 E18 K20 L108 D109 T115 A116 R128 F162 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 Y336
BS02	rna	A	Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426	Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426
BS03	MN	A	D63 T64 K65 C249 S250 D251	D63 T64 K65 C249 S250 D251

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4wzm, PDBe:4wzm, PDBj:4wzm
• PDBsum: 4wzm
• PubMed: 25903341
• UniProt: P03311|POLG_FMDVS Genome polyprotein