Structure of PDB 4wz6 Chain A

Receptor sequence
>4wz6A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEVVMENVTAFWEEGFGELFEKAKQSLLGTPVLKDINFKIERGQLLAVA
GSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQNSWIMPGTIKENII
GVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGITLSGGQRARISLARA
VYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLK
KADKILILHEGSSYFYGTFSELQNLRPDFSSKLMSFDQFSAERRNSILTE
TLHRFSLE
3D structure
PDB4wz6 Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A W401 V440 T460 G461 G463 K464 T465 S466 Q493 W13 V33 T53 G54 G56 K57 T58 S59 Q86 MOAD: Kd=1.4uM
PDBbind-CN: -logKd/Ki=5.60,Kd=2.5uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:4wz6, PDBe:4wz6, PDBj:4wz6
PDBsum4wz6
PubMed26444971
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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