Structure of PDB 4wyz Chain A

Receptor sequence
>4wyzA (length=125) Species: 9913 (Bos taurus) [Search protein sequence]
MKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHE
SLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKT
TQANKHIIVGCEGNPYVPVHFDASV
3D structure
PDB4wyz Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity.
ChainA
Resolution1.449 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H13 K42 H120 F121 D122
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U3P A H12 K41 N44 T45 F120 H13 K42 N45 T46 F121 MOAD: Kd=50uM
PDBbind-CN: -logKd/Ki=4.30,Kd=50uM
BindingDB: Ki=78500nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wyz, PDBe:4wyz, PDBj:4wyz
PDBsum4wyz
PubMed26655472
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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