Structure of PDB 4wxu Chain A

Receptor sequence
>4wxuA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGT
DVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRT
VIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYS
TDDAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYT
SADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLN
MVTYDIKLS
3D structure
PDB4wxu Structural basis for misfolding in myocilin-associated glaucoma.
ChainA
Resolution2.092 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D380 N428 A429 I477 D478 D137 N185 A186 I234 D235
BS02 GOL A G252 E253 P466 F467 K468 G9 E10 P223 F224 K225
BS03 GOL A M271 R272 V328 V329 Y479 N480 F487 M28 R29 V85 V86 Y236 N237 F244
BS04 NA A G326 A327 D380 L381 D478 G83 A84 D137 L138 D235
External links
PDB RCSB:4wxu, PDBe:4wxu, PDBj:4wxu
PDBsum4wxu
PubMed25524706
UniProtQ99972|MYOC_HUMAN Myocilin (Gene Name=MYOC)

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