Structure of PDB 4wx9 Chain A

Receptor sequence
>4wx9A (length=161) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
VHYRTIDSPIGPLTLAGHGSVLTNLRMLEQTSRTHWTPDPGAFSGAVDQL
NAYFAGELTEFDVELDLRGTDFQQRVWKALLTIPYGETRSYGEIADQIGA
PGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGYGGGINRKRALLELEK
SRAPADLTLFD
3D structure
PDB4wx9 Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.63: methylated-DNA--[protein]-cysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y95 A108 R109 G112 L113 N115 G116 C126 A132 T137 G138 Y139 G140 Y91 A104 R105 G108 L109 N111 G112 C122 A128 T133 G134 Y135 G136
BS02 dna A T74 F76 G106 T70 F72 G102
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair
GO:0032259 methylation
GO:0051409 response to nitrosative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:4wx9, PDBe:4wx9, PDBj:4wx9
PDBsum4wx9
PubMed26512127
UniProtP9WJW5|OGT_MYCTU Methylated-DNA--protein-cysteine methyltransferase (Gene Name=ogt)

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