Structure of PDB 4wx6 Chain A

Receptor sequence
>4wx6A (length=204) Species: 31545 (Human adenovirus D8) [Search protein sequence]
SGSSEQELAAIVRDLGCGPYFLGTHDKRFPGFLAGNKLACAIVNTAGRET
GGVHWLAFGWNPRSRTCYMFDPFGFSDRRLKQIYSFEYEAMLRRSALALS
PDRCLSLEQSTQTVQGPDSAACGLFCCMFLHAFVHWPDRPMDGNPTMNLL
TGVPNGMLQSPQVLPTLRRNQEKLYRFLAHHSPYFRSHRAAIEHATAFDK
MKQL
3D structure
PDB4wx6 Structure-based design and optimization of potent inhibitors of the adenoviral protease.
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H54 D71 Q115 C122
Catalytic site (residue number reindexed from 1) H54 D71 Q115 C122
Enzyme Commision number 3.4.22.39: adenain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R93 R103 C104 L105 L107 E108 Q109 S110 T111 Q112 M141 D142 M147 L150 G152 R93 R103 C104 L105 L107 E108 Q109 S110 T111 Q112 M141 D142 M147 L150 G152
BS02 3VK A G2 S3 S4 E5 T24 D26 N44 A46 R48 G51 G52 V53 H54 W55 F73 Y84 C122 G2 S3 S4 E5 T24 D26 N44 A46 R48 G51 G52 V53 H54 W55 F73 Y84 C122 PDBbind-CN: -logKd/Ki=9.00,IC50<0.001uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0042025 host cell nucleus
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wx6, PDBe:4wx6, PDBj:4wx6
PDBsum4wx6
PubMed25571794
UniProtB9A5C1

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