Structure of PDB 4wx4 Chain A

Receptor sequence

>4wx4A (length=201) Species: 31545 (Human adenovirus D8) [Search protein sequence]

SGSSEQELAAIVRDLGCGPYFLGTHDKRFPGFLAGNKLACAIVNTAGRET
GGVHWLAFGWNPRSRTCYMFDPFGFSDRRLKQIYSFEYEAMLRRSALALS
PDRCLSLEQSTQTVQGPDSAACGLFCCMFLHAFVHWPDRPMDGNPTMNLL
TGVPNGMLQSPQVLPTLRRNQEKLYRFLAHHSPYFRSHRAAIEHATAFDK
M

3D structure

PDB

4wx4 Structure-based design and optimization of potent inhibitors of the adenoviral protease.

Chain

Resolution

1.03 Å

3D
structure

Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Catalytic site (original residue number in PDB)	H54 D71 Q115 C122
Catalytic site (residue number reindexed from 1)	H54 D71 Q115 C122
Enzyme Commision number	3.4.22.39: adenain.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R65 D77 E89 L92 R93 R103 C104 L105 S106 L107 E108 Q109 S110 T111 Q112 M141	R65 D77 E89 L92 R93 R103 C104 L105 S106 L107 E108 Q109 S110 T111 Q112 M141
BS02	3VF	A	S1 S3 S4 E5 T24 H25 D26 N44 G47 R48 G51 G52 V53 W55 A120 C122	S1 S3 S4 E5 T24 H25 D26 N44 G47 R48 G51 G52 V53 W55 A120 C122	PDBbind-CN: -logKd/Ki=9.22,IC50=0.0006uM
BS03	GLY	A	D142 M147 L150 G152	D142 M147 L150 G152

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004197	cysteine-type endopeptidase activity
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0042025	host cell nucleus
GO:0044423	virion component

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4wx4, PDBe:4wx4, PDBj:4wx4
PDBsum	4wx4
PubMed	25571794
UniProt	B9A5C1

[Back to BioLiP]