Structure of PDB 4ww9 Chain A

Receptor sequence
>4ww9A (length=238) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
EFIDKVSSYLTPDVDIAPISQGAIVFTTTTHPYLPRAKDSHQKYIIKYRP
RTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSN
LKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR
DGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWI
MEGFEEVYREQGAKGAKKLKEVTKRFEEVRLRGRKRSM
3D structure
PDB4ww9 Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex.
ChainA
Resolution1.951 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A K52 D182 K47 D161
BS02 ADP A S23 I50 E107 F108 L109 I181 D182 S20 I45 E86 F87 L88 I160 D161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0000282 cellular bud site selection
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0008033 tRNA processing
GO:0016310 phosphorylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0000408 EKC/KEOPS complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ww9, PDBe:4ww9, PDBj:4ww9
PDBsum4ww9
PubMed25735745
UniProtP53323|BUD32_YEAST EKC/KEOPS complex subunit BUD32 (Gene Name=BUD32)

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