Structure of PDB 4wvy Chain A

Receptor sequence
>4wvyA (length=427) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
ISEVRGNTRDHRTAAHTHIKGLGLNSSGIAEKQAAGFVGQCAAREACGVV
VDLIKAHKMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPITGSEIY
STEVKKTEVLMENFRRAIGLRVRETKDVYEGEVTEMTPETLLIGLKSARG
QKKLRLDPSIYEAIQKERVQVGDVIYIETNTGACKRVGRSDAYATEFDLE
AEEYVPIPKGEVHKKKEIVQDVTLHDLDVANARPIISMMGQLMKPKMTEI
TDKLRMEINKVVQKYINQGVAELIPGVLFIDEAHMLDIECFTYLNKALES
PIAPIVVLASNRGIATIRGADDLKAAHGIPPDFLQRLLIIPTHPYEPDEI
RRIVRIRAQTEGVQLTDAAVDRVAEHGVRISLRYCLQLLAPASILARVNG
RTQVDVQDIAEAEELFLDARRSANILT
3D structure
PDB4wvy Structural Basis for Dodecameric Assembly States and Conformational Plasticity of the Full-Length AAA+ ATPases Rvb1Rvb2.
ChainA
Resolution3.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A A18 H19 F40 V41 P73 G74 T75 G76 K77 T78 D303 Y367 I375 R379 L404 R405 A15 H16 F37 V38 P70 G71 T72 G73 K74 T75 D281 Y345 I353 R357 L382 R383
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0097255 R2TP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wvy, PDBe:4wvy, PDBj:4wvy
PDBsum4wvy
PubMed25661652
UniProtG0RYI5

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