Structure of PDB 4wvs Chain A

Receptor sequence
>4wvsA (length=79) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFA
CGGKLKNWEPGDRAWSEHRRHFPNCFFVL
3D structure
PDB4wvs The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q197 K206 L207 K208 N209 W210 D214 E219 H223 F224 Q45 K54 L55 K56 N57 W58 D62 E67 H71 F72
BS02 ZN A C200 C203 H220 C227 C48 C51 H68 C75
Gene Ontology
Molecular Function
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0043066 negative regulation of apoptotic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4wvs, PDBe:4wvs, PDBj:4wvs
PDBsum4wvs
PubMed25695766
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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