Structure of PDB 4wv7 Chain A

Receptor sequence
>4wv7A (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]
DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYE
GERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKS
TGKANKITITNDLSKEEIERMVQEAEKYKAEDEVQRERVSKNALE
3D structure
PDB4wv7 The novolactone natural product disrupts the allosteric regulation of hsp70.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3UM A E444 L456 I480 G484 I485 L486 L510 E50 L62 I86 G90 I91 L92 L113
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:4wv7, PDBe:4wv7, PDBj:4wv7
PDBsum4wv7
PubMed25544045
UniProtP0DMV8|HS71A_HUMAN Heat shock 70 kDa protein 1A (Gene Name=HSPA1A)

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