Structure of PDB 4wsq Chain A

Receptor sequence
>4wsqA (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFV
NNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDF
CRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLK
VENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAP
EMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPD
NSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSP
IPAKLPEPVKASEAAAK
3D structure
PDB4wsq Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D176 K178 N181 D194 T222
Catalytic site (residue number reindexed from 1) D148 K150 N153 D166 T194
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H185 D186 H189 H157 D158 H161
BS02 ZN A D127 H185 D99 H157
BS03 ZN A D176 D194 D148 D166
BS04 KSA A A53 V60 A72 K74 M126 D127 F128 C129 G132 Q133 E180 L183 C193 D194 A25 V32 A44 K46 M98 D99 F100 C101 G104 Q105 E152 L155 C165 D166
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4wsq, PDBe:4wsq, PDBj:4wsq
PDBsum4wsq
PubMed26853940
UniProtQ2M2I8|AAK1_HUMAN AP2-associated protein kinase 1 (Gene Name=AAK1)

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