Structure of PDB 4wsi Chain A

Receptor sequence

>4wsiA (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]

ESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSG
LLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPA
KETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAY
REGDEDNQPLAGLVPGKEEILTYEEMSLYHQPANRKRPIILIGPQNCGQN
ELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAG
KFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPY
IIFIAPPSQERLRALLELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQ
ELLRLINKLDTEPQWVPSTWLR

3D structure

PDB

4wsi Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.

Chain

Resolution

2.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	P266 L267 A269 T270 V271 N273 S281 R282 N315 F318 L321 P365 E368 L369 P512 R516 D527 Y528 F551 Y556 S576 R578	P23 L24 A26 T27 V28 N30 S38 R39 N72 F75 L78 P122 E125 L126 P219 R223 D234 Y235 F258 Y263 S283 R285

External links

PDB	RCSB:4wsi, PDBe:4wsi, PDBj:4wsi
PDBsum	4wsi
PubMed	25385611
UniProt	Q8N3R9\|PALS1_HUMAN Protein PALS1 (Gene Name=PALS1)

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