Structure of PDB 4wsb Chain A

Receptor sequence

>4wsbA (length=699) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDDNAMLKHRFEIIEGQERNIAWTIVNSICNMTEN
SKPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSF
DGEEMATDDEYILDEESRARIKTRLFVLRQELATALEEEFSYPPTFQRLA
NQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPRTI
RELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDTFW
GWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKWGL
GEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELTNS
NWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTALL
NSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVVNF
ISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTNGT
SKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRENDWP
IGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLLIQ
AFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSMG

3D structure

• PDB: 4wsb Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
• Chain: A
• Resolution: 2.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	M472 H505 L506 R507	M457 H490 L491 R492
BS02	rna	A	K281 H326 K328 W363 G366 G368 Q369 A370 P371 Y388 K389 S390 P392 R503 H505 V512 N514 K534 R561 T562 N563 G564 K569	K266 H311 K313 W348 G351 G353 Q354 A355 P356 Y373 K374 S375 P377 R488 H490 V497 N499 K519 R546 T547 N548 G549 K554

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting

External links

• PDB: RCSB:4wsb, PDBe:4wsb, PDBj:4wsb
• PDBsum: 4wsb
• PubMed: 25409151
• UniProt: H6QM92