Structure of PDB 4wpz Chain A

Receptor sequence
>4wpzA (length=387) Species: 33903 (Streptomyces avermitilis) [Search protein sequence]
PIAFPFPDPPSVCELPPELAEIRDGQSVVEVKFPDGISGWMVTKHADVRK
VLVDSRFSSKVTETGKLMNESLVGMDAPEHTRLRKLVTKAFTARRVETLR
PRITELVGQLLDELETLPRPVDLVKNFSVPLPVRVICELLGVPAGDQDTF
HAWSNALLGDWQQVVEKEAATVSLVNYFGELIAVKRENPADDLISELIAI
SDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLRD
NREAIPKAVDELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPA
VATANRDPEVFEDGERLNVTRENNPHLAFGAGIHHCLGAQLARIELQEAL
GAILDRMPQVRLAVPESELRLKSASIIRGLESLPITW
3D structure
PDB4wpz Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G176 A239 E242 T243 T244 T288 C353 L354 G355 E362 I394
Catalytic site (residue number reindexed from 1) G159 A222 E225 T226 T227 T271 C336 L337 G338 E345 I377
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A L89 V90 H97 R101 F108 I236 A239 G240 T243 T244 L285 I291 R294 A345 F346 H351 C353 L354 G355 A359 L72 V73 H80 R84 F91 I219 A222 G223 T226 T227 L268 I274 R277 A328 F329 H334 C336 L337 G338 A342
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4wpz, PDBe:4wpz, PDBj:4wpz
PDBsum4wpz
PubMed25849761
UniProtQ93HJ0

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