Structure of PDB 4wpv Chain A

Receptor sequence
>4wpvA (length=586) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
PTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEFQRLCDQLVEAGTFIRLN
PEKHKNSYLALSDPSDVARVASRTYICSAKEIDAGPTNNWMDPGEMRSIM
KDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRM
GKAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETRE
IWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKA
YYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVN
PEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDGDVWWEGLEGD
PQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPILAPEWDDPQGVPI
SGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSEQTNVRRDPMAMLPFL
GYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGENSR
VLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALAVDAD
EWRQELPLIEEWLQFVGEKLPTGVKDEFDALKERLG
3D structure
PDB4wpv Crystal Structure of E83A from Mtb PEPCK in complex with Zn2+ and phosphate ion
ChainA
Resolution1.672 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R81 Y220 K229 H249 S271 C273 D296 R389
Catalytic site (residue number reindexed from 1) R69 Y208 K217 H237 S259 C261 D284 R377
Enzyme Commision number 4.1.1.32: phosphoenolpyruvate carboxykinase (GTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H249 D296 H237 D284
Gene Ontology
Molecular Function
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0016831 carboxy-lyase activity
GO:0017076 purine nucleotide binding
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006094 gluconeogenesis
GO:0019543 propionate catabolic process
GO:0033993 response to lipid
GO:0042594 response to starvation
GO:0046327 glycerol biosynthetic process from pyruvate
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4wpv, PDBe:4wpv, PDBj:4wpv
PDBsum4wpv
PubMed
UniProtA5TYT6|PCKG_MYCTA Phosphoenolpyruvate carboxykinase [GTP] (Gene Name=pckG)

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