Structure of PDB 4wpl Chain A

Receptor sequence
>4wplA (length=229) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ASMTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSN
VLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIF
DEYTADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAV
TECAIRALAARAAPLVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSAS
RGFFGSRPFSRANELLVGMGAEPIDWRLP
3D structure
PDB4wpl Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.
ChainA
Resolution1.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D68 Y70 F81 H191
Catalytic site (residue number reindexed from 1) D70 Y72 F83 H193
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 URA A G66 Q67 D68 Y70 S80 F81 N127 H191 G68 Q69 D70 Y72 S82 F83 N129 H193
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0097510 base-excision repair, AP site formation via deaminated base removal
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:4wpl, PDBe:4wpl, PDBj:4wpl
PDBsum4wpl
PubMed26143923
UniProtP9WFQ9|UNG_MYCTU Uracil-DNA glycosylase (Gene Name=ung)

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