Structure of PDB 4wp9 Chain A

Receptor sequence
>4wp9A (length=165) Species: 1764 (Mycobacterium avium) [Search protein sequence]
GAMGSRVVILFTDIEESTALNERIGDRAWVKLISSHDKLVSDLVRRQSGH
VVKSQGDGFMVAFARPEQAVRCGIELQRALRRNAEIRVRIGIHMGRSVRR
GDDLFGRNVAMAARVAAQAAGGEILVSQPVRDALSRSDGIRFDDGREVEL
KGFSGTYRLFAVLAS
3D structure
PDB4wp9 Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase
ChainA
Resolution1.382 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A L204 F207 L150 F153
BS02 MG A D61 D105 D13 D57
BS03 ZDA A D61 I62 E64 S65 T66 Q103 G104 D105 D13 I14 E16 S17 T18 Q55 G56 D57
BS04 CA A D61 I62 D105 D13 I14 D57
BS05 CA A R168 Q172 L204 K205 R114 Q118 L150 K151
BS06 ZDA A K101 M108 D157 V163 A164 K205 K53 M60 D103 V109 A110 K151
Gene Ontology
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4wp9, PDBe:4wp9, PDBj:4wp9
PDBsum4wp9
PubMed25916753
UniProtQ5UFR5

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