Structure of PDB 4wp8 Chain A

Receptor sequence
>4wp8A (length=163) Species: 1764 (Mycobacterium avium) [Search protein sequence]
FQGAMGSRVVILFTDIEESTALNERIGDRAWVKLISSHDKLVSDLVRRQS
GHVVKSQGDGFMVAFARPEQAVRCGIELQRALRRNANREIRVRIGIHMGR
SVRRGDDLFGRNVAMAARVAAQAAGGEILVSQPVRDALGIRFDDGREVEL
KGFSGTYRLFAVL
3D structure
PDB4wp8 Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D61 I62 D105 D15 I16 D59
BS02 ZDA A D61 I62 E63 E64 S65 T66 Q103 G104 D105 R143 D15 I16 E17 E18 S19 T20 Q57 G58 D59 R93
BS03 ZDA A V163 A164 A167 R168 K205 V113 A114 A117 R118 K151
Gene Ontology
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4wp8, PDBe:4wp8, PDBj:4wp8
PDBsum4wp8
PubMed25916753
UniProtQ5UFR5

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