Structure of PDB 4wnp Chain A

Receptor sequence
>4wnpA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
GTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKS
QTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHA
MRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANP
NSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWS
IGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLL
ALLQRNHKDRMDFDEFFHHPFLDA
3D structure
PDB4wnp Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors.
ChainA
Resolution1.88 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 Q142 N143 D165 S184
Catalytic site (residue number reindexed from 1) D132 K134 Q136 N137 D159 S178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3RJ A I22 A44 M92 E93 Y94 C95 G98 Q142 N143 L145 I16 A38 M86 E87 Y88 C89 G92 Q136 N137 L139 MOAD: ic50=8nM
PDBbind-CN: -logKd/Ki=8.10,IC50=8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010506 regulation of autophagy

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Molecular Function
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Biological Process
External links
PDB RCSB:4wnp, PDBe:4wnp, PDBj:4wnp
PDBsum4wnp
PubMed25551253
UniProtO75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (Gene Name=ULK1)

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