Structure of PDB 4wnm Chain A

Receptor sequence
>4wnmA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
VYEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNPAL
KDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQN
RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDF
GLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW
EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDV
ENRPGFAAVELRLRNYYYDVVNH
3D structure
PDB4wnm A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D494 A496 R498 N499 D512 K533
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149 K170
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3RT A L377 A400 M448 M450 A451 G454 P455 K458 N499 L501 S511 D512 L18 A41 M85 M87 A88 G91 P92 K95 N136 L138 S148 D149 MOAD: Ki=18nM
PDBbind-CN: -logKd/Ki=7.59,IC50=0.026uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4wnm, PDBe:4wnm, PDBj:4wnm
PDBsum4wnm
PubMed26756335
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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