Structure of PDB 4wnd Chain A

Receptor sequence

>4wndA (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]

MEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLG
NAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFD
EAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCFPEEVRDA
LQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQ
RLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKD
RAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWS
LGNAYTALGNHDQAMHFAEKHLEISREVG

3D structure

PDB

4wnd Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN

Chain

Resolution

1.5 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	L18 L22 E25 K52 A56 S59 Q60 N63 D81 G93 K96 N100 N103 H121 R136 Y139 H146 R196 N200 N203 L207 R221 R235 R236 N240 Q276 Y279 N283 T286 L287 R316 W319	L6 L10 E13 K40 A44 S47 Q48 N51 D69 G81 K84 N88 N91 H109 R124 Y127 H134 R176 N180 N183 L187 R201 R215 R216 N220 Q256 Y259 N263 T266 L267 R296 W299

External links

PDB	RCSB:4wnd, PDBe:4wnd, PDBj:4wnd
PDBsum	4wnd
PubMed	25664792
UniProt	P81274\|GPSM2_HUMAN G-protein-signaling modulator 2 (Gene Name=GPSM2)

[Back to BioLiP]