Structure of PDB 4wn0 Chain A

Receptor sequence
>4wn0A (length=277) Species: 8355 (Xenopus laevis) [Search protein sequence]
GYRSCNEIKSSDSRAPDGIYTLATEDGESYQTFCDMTTNGGGWTLVASVH
ENNMFGKCTVGDRWSTQQGNMLQNPEGDGNWANYATFGLPEGATSDDYKN
PGYYDIEAKNLALWHVPNKTPMVMWRNSSILRYRTQNGFLTEEGGNLFEL
YKKYPVKYDIGKCLADNGPAVPVVYDLGSAEKTASLYSPNGRSEFTPGFV
QFRAVNSERATLALCAGVKVKGCNVEHHCIGGGGYIPEGSPRQCGDFAAL
DWDGYGTNLGWSASKQIIEAAVMLFYR
3D structure
PDB4wn0 Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E116 N118 G121 D127 E51 N53 G56 D62
BS02 CA A H115 G126 D162 D311 H50 G61 D97 D246
BS03 CA A N289 E291 E303 N224 E226 E238
BS04 PO4 A R191 R197 R126 R132
BS05 G3P A N289 H292 E303 W326 N224 H227 E238 W261 MOAD: ic50=0.6mM
PDBbind-CN: -logKd/Ki=3.22,IC50=0.6mM
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0034214 protein hexamerization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030133 transport vesicle
GO:0030141 secretory granule
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wn0, PDBe:4wn0, PDBj:4wn0
PDBsum4wn0
PubMed26755729
UniProtQ5PPM0|ITLN1_XENLA Intelectin-1 (Gene Name=itln1)

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