Structure of PDB 4wmy Chain A

Receptor sequence
>4wmyA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
CSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWT
LVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAAT
SDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLG
HNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQRE
FTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQC
GDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR
3D structure
PDB4wmy Recognition of microbial glycans by human intelectin-1.
ChainA
Resolution1.601 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A H86 G97 D133 D282 H56 G67 D103 D252
BS02 CA A E87 D89 G92 D98 E57 D59 G62 D68
BS03 CA A N260 E262 E274 N230 E232 E244
BS04 3S6 A N260 H263 E274 Y297 N230 H233 E244 Y267 MOAD: Kd=85nM
PDBbind-CN: -logKd/Ki=7.07,Kd=85nM
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0009624 response to nematode
GO:0046326 positive regulation of D-glucose import
GO:0070207 protein homotrimerization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031526 brush border membrane
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0070062 extracellular exosome
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wmy, PDBe:4wmy, PDBj:4wmy
PDBsum4wmy
PubMed26148048
UniProtQ8WWA0|ITLN1_HUMAN Intelectin-1 (Gene Name=ITLN1)

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