Structure of PDB 4wma Chain A

Receptor sequence
>4wmaA (length=299) Species: 10090 (Mus musculus) [Search protein sequence]
VVPVDYHLLMMFTKAEHNAPLQAKARVALSSLLRLAKFEAHEVLNLHFVS
EEASREVAKALLRELLPPAAGFKCKVIFHDVAVLTDKLFPVVEAMQKYFS
AGSGTYYSDSIFFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFD
NFLPGAVIGIAREMQPVYRHTFWQFRHENPKTRVGDPPPEGLPGFNSGVM
LLNLEAMRQSPLYSHLLEPSWVQQLADKYHFRGHLGDQDFFTMIGMEHPE
LFHVLDCTWNRQLCTWWRDHGYSDVFQAYFRCEGHVKIYHGNCNTPIPE
3D structure
PDB4wma Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.62: xylosyl alpha-1,3-xylosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A W358 W359 W266 W267
BS02 XYS A E255 Q257 W359 C385 E163 Q165 W267 C293
BS03 MN A D225 D227 H382 D133 D135 H290
BS04 UPG A M103 F104 T105 L113 D225 L226 D227 S289 Q330 N384 M11 F12 T13 L21 D133 L134 D135 S197 Q238 N292
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0035252 UDP-xylosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4wma, PDBe:4wma, PDBj:4wma
PDBsum4wma
PubMed26414444
UniProtQ3U4G3|XXLT1_MOUSE Xyloside xylosyltransferase 1 (Gene Name=Xxylt1)

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