Structure of PDB 4wlz Chain A

Receptor sequence
>4wlzA (length=286) Species: 10090 (Mus musculus) [Search protein sequence]
PVDYHLLMMFTKAEHNAPLQAKARVALSSLLRLAKFEAHEVLNLHFVSEE
ASREVAKALLRELLFKCKVIFHDVAVLTDKLFPVVEAMQKYFSAYYSDSI
FFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFDNFLPGAVIGIA
REMQPVYRHTFWQFRHENPKTRVGDPPPEGLPGFNSGVMLLNLEAMRQSP
LYSHLLEPSWVQQLADKYHFRGHLGDQDFFTMIGMEHPELFHVLDCTWNR
QLCTWWRDHGYSDVFQAYFRCEGHVKIYHGNCNTPI
3D structure
PDB4wlz Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.
ChainA
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.62: xylosyl alpha-1,3-xylosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D225 D227 H382 D122 D124 H279
BS02 UDP A M103 F104 T105 L113 D225 L226 D227 H382 N384 M9 F10 T11 L19 D122 L123 D124 H279 N281
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0035252 UDP-xylosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4wlz, PDBe:4wlz, PDBj:4wlz
PDBsum4wlz
PubMed26414444
UniProtQ3U4G3|XXLT1_MOUSE Xyloside xylosyltransferase 1 (Gene Name=Xxylt1)

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