Structure of PDB 4wlb Chain A

Receptor sequence
>4wlbA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
GSAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQ
RKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAME
VVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSA
LHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHR
QSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB4wlb A reversed sulfonamide series of selective RORc inverse agonists.
ChainA
Resolution1.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 P500 L501 E504 K77 Q87 P241 L242 E245
BS02 3QQ A Q286 L287 C320 H323 M365 R367 A368 F378 I400 H479 Q27 L28 C61 H64 M106 R108 A109 F119 I141 H220 MOAD: ic50=0.18uM
PDBbind-CN: -logKd/Ki=6.74,IC50=0.18uM
BindingDB: IC50=180nM,EC50=520nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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External links
PDB RCSB:4wlb, PDBe:4wlb, PDBj:4wlb
PDBsum4wlb
PubMed25453817
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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