Structure of PDB 4wk4 Chain A

Receptor sequence

>4wk4A (length=450) Species: 9606 (Homo sapiens)

FNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVL
QGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQW
FGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAP
CRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQI
AESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVA
GVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLD
DLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGR
FGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQ
VLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRP

3D structure

• PDB: 4wk4 Metal ion and ligand binding of integrin alpha 5 beta 1.
• Chain: A
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y186 F187 Q221 S224 D227	Y186 F187 Q221 S224 D227
BS02	MAN	A	A222 S223	A222 S223
BS03	CA	A	E239 S241 D243 T245 D247	E239 S241 D243 T245 D247
BS04	CA	A	D293 N295 D297 L299 D301	D293 N295 D297 L299 D301
BS05	CA	A	D360 D362 D364 Y366 D368	D360 D362 D364 Y366 D368
BS06	CA	A	D424 D426 N428 Y430 D432	D424 D426 N428 Y430 D432

Gene Ontology

Biological Process

• GO:0007155 cell adhesion

Cellular Component

• GO:0008305 integrin complex

External links

• PDB: RCSB:4wk4, PDBe:4wk4, PDBj:4wk4
• PDBsum: 4wk4
• PubMed: 25475857
• UniProt: P08648|ITA5_HUMAN Integrin alpha-5 (Gene Name=ITGA5)