Structure of PDB 4wj7 Chain A

Receptor sequence
>4wj7A (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]
PDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGH
LTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVV
LKTAQDEACCLVILAAESKVAAEELCCLLGQVFQVVY
3D structure
PDB4wj7 Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations.
ChainA
Resolution2.753 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P82 S83 H137 D138 I139 A140 A141 V142 S143 Y144 R146 A158 C210 F217 P28 S29 H83 D84 I85 A86 A87 V88 S89 Y90 R92 A104 C126 F133
External links
PDB RCSB:4wj7, PDBe:4wj7, PDBj:4wj7
PDBsum4wj7
PubMed25525273
UniProtQ9BSQ5|CCM2_HUMAN Cerebral cavernous malformations 2 protein (Gene Name=CCM2)

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