Structure of PDB 4wiv Chain A

Receptor sequence
>4wivA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4wiv Biased multicomponent reactions to develop novel bromodomain inhibitors.
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3P2 A W81 F83 V87 L92 N140 I146 W40 F42 V46 L51 N99 I105 MOAD: Kd=550nM
PDBbind-CN: -logKd/Ki=6.26,Kd=550nM
BindingDB: IC50=637nM,Kd=550nM
External links
PDB RCSB:4wiv, PDBe:4wiv, PDBj:4wiv
PDBsum4wiv
PubMed25314271
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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