Structure of PDB 4wis Chain A

Receptor sequence
>4wisA (length=654) Species: 660122 (Fusarium vanettenii 77-13-4) [Search protein sequence]
GVDFVIHYKVPAAERDEAEAGFVQLIRALTTVGLATEVRHGENESLLVFV
KVASPDLFAKQVYRARLGDWLHGVRVSAPHNDIAQALQDEPVVEAERLRL
IYLMITKPHNEWKHVESIFPLHSHSFNKEWIKKWSSKYTLEQTDIDNIRD
KFGESVAFYFAFLRSYFRFLVIPSAFGFGAWLLLGQFSYLYALLCGLWSV
VFFEYWKKQEVDLAVQWGVRGVSSIQQSRPEFEWEHEAEDPITGEPVKVY
PPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGPGKQYLG
FLPTIFLVIGTPTISGVLMGAAEKLNAMENYATVDAHDAALIQKQFVLNF
MTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTFSEKELPTREFQIN
PARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQAEFLQRVREECTLEE
YDVSGDYREMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISS
RRPIPWRTDSIGPWLTALSFLSWLGSITSSAIVYLCSNASPLKAWGLLLS
ILFAEHFYLVVQLAVRFVLSKLDSPGLQKERKERFQTKKRLLQENLGQDA
AAAPGIEHSEKITREALEEEARQASIEMFWQRQRGMQETIEIGRRMIEQQ
LAAG
3D structure
PDB4wis X-ray structure of a calcium-activated TMEM16 lipid scramblase.
ChainA
Resolution3.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E452 D503 E506 E535 D539 E423 D456 E459 E488 D492
BS02 CA A N448 F449 E452 E506 E535 N419 F420 E423 E459 E488
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4wis, PDBe:4wis, PDBj:4wis
PDBsum4wis
PubMed25383531
UniProtC7Z7K1

[Back to BioLiP]