Structure of PDB 4whw Chain A

Receptor sequence
>4whwA (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPT
3D structure
PDB4whw Direct photocapture of bromodomains using tropolone chemical probes
ChainA
Resolution1.345 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3OT A W81 P82 F83 V87 L92 L94 N140 I146 W39 P40 F41 V45 L50 L52 N98 I104 BindingDB: IC50=350nM
External links
PDB RCSB:4whw, PDBe:4whw, PDBj:4whw
PDBsum4whw
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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