Structure of PDB 4wh9 Chain A

Receptor sequence
>4wh9A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
HRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIV
DCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHSE
FSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCE
PQDYRPMNHEAFKDELKTFRLKTRSWA
3D structure
PDB4wh9 Inhibition of CDC25B Phosphatase Through Disruption of Protein-Protein Interaction.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3M8 A D397 L398 C484 R485 R488 R492 D23 L24 C110 R111 R114 R118 MOAD: ic50=2.2mM
PDBbind-CN: -logKd/Ki=3.00,IC50=1mM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:1902751 positive regulation of cell cycle G2/M phase transition

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4wh9, PDBe:4wh9, PDBj:4wh9
PDBsum4wh9
PubMed25423142
UniProtP30305|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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