Structure of PDB 4wh6 Chain A

Receptor sequence
>4wh6A (length=200) [Search protein sequence]
SHMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVE
GEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDK
DLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPR
PISYLKGSSGGPLLCPAGHAVGIFKAAVSTRGVAKAVDFIPVESLETTMR
3D structure
PDB4wh6 Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease.
ChainA
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 S1139
Catalytic site (residue number reindexed from 1) H77 D101 G157 S159
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 H1149 C117 C119 C165 H169
BS02 2R9 A Q1041 F1043 H1057 D1081 L1135 K1136 G1137 S1139 F1154 K1155 A1156 A1157 Q61 F63 H77 D101 L155 K156 G157 S159 F174 K175 A176 A177
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4wh6, PDBe:4wh6, PDBj:4wh6
PDBsum4wh6
PubMed25243902
UniProtA8DG50

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