Structure of PDB 4wfr Chain A

Receptor sequence
>4wfrA (length=204) Species: 10090 (Mus musculus) [Search protein sequence]
KDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISEKLE
LVSYFGKRPPGVLHCATKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSIS
ALFVTPKTAGAQVVLTDQELQLWPSDSASEGLPPGSRAHVTLGCAADVQP
VQTGLDLLDILQQVKGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFT
GYYG
3D structure
PDB4wfr Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2AM A Y168 H230 F235 H309 T311 P320 V321 Y7 H64 F69 H139 T141 P150 V151
Gene Ontology
Molecular Function
GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Biological Process
GO:0009214 cyclic nucleotide catabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wfr, PDBe:4wfr, PDBj:4wfr
PDBsum4wfr
PubMed26563764
UniProtP16330|CN37_MOUSE 2',3'-cyclic-nucleotide 3'-phosphodiesterase (Gene Name=Cnp)

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