Structure of PDB 4wf8 Chain A

Receptor sequence
>4wf8A (length=192) [Search protein sequence]
KGSVVIVGRINLSGDTAYAQQTRGAAACQETSQTGRDKNQVEGEVQIVST
ATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAP
QGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGS
SGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTMR
3D structure
PDB4wf8 Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 S1139
Catalytic site (residue number reindexed from 1) H69 D93 G149 S151
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 C109 C111 C157
BS02 2R9 A F1043 H1057 V1078 D1081 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 D1168 F55 H69 V90 D93 L147 K148 G149 S151 F166 R167 A168 A169 D180
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4wf8, PDBe:4wf8, PDBj:4wf8
PDBsum4wf8
PubMed25243902
UniProtX2G809

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