Structure of PDB 4wf6 Chain A

Receptor sequence
>4wf6A (length=503) Species: 1392 (Bacillus anthracis) [Search protein sequence]
SRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEE
KELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNPLSEKEK
EFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALL
HQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKK
NFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQR
NIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKA
LGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLV
DGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSK
GVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGS
NLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFI
INS
3D structure
PDB4wf6 Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
ChainA
Resolution2.6521 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H413 E414 H417 Y455 E462
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H686 H690 E735 H413 H417 E462
BS02 407 A S655 K656 G657 L658 V675 L677 H686 E687 H690 Y728 E735 E739 S382 K383 G384 L385 V402 L404 H413 E414 H417 Y455 E462 E466 PDBbind-CN: -logKd/Ki=6.30,IC50=0.5uM
BindingDB: IC50=1600nM
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:4wf6, PDBe:4wf6, PDBj:4wf6
PDBsum4wf6
PubMed26492514
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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