Structure of PDB 4wf5 Chain A

Receptor sequence
>4wf5A (length=188) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence]
AQYEDGKQYTTLEKPVAGAPQVLEFFSFFCPHCYQFEEVLHISDNVKKKL
PEGVKMTKYHVNFMGGDLGKDLTQAWAVAMALGVEDKVTVPLFEGVQKTQ
TIRSASDIRDVFINAGIKGEEYDAAWNSFVVKSLVAQQEKAAADVQLRGV
PAMFVNGKYQLNPQGMDTSNMDVFVQQYADTVKYLSEK
3D structure
PDB4wf5 Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.8.4.2: protein-disulfide reductase (glutathione).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WF4 A T168 F174 T168 F174 MOAD: Kd=777uM
BS02 WF4 A H32 Q35 F36 L40 H32 Q35 F36 L40 MOAD: Kd=777uM
Gene Ontology
Molecular Function
GO:0015036 disulfide oxidoreductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
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Cellular Component
External links
PDB RCSB:4wf5, PDBe:4wf5, PDBj:4wf5
PDBsum4wf5
PubMed25556635
UniProtA0A0H2UL03

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