Structure of PDB 4wdf Chain A

Receptor sequence
>4wdfA (length=213) Species: 10090 (Mus musculus) [Search protein sequence]
DFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEKL
ELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSI
SALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCA
ADVQPAQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTK
KMEVKAIFTGYYG
3D structure
PDB4wdf Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.
ChainA
Resolution2.0 Å
3D
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Enzymatic activity
Enzyme Commision number 3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A2P A Y168 H230 F235 H309 T311 P320 A321 Y6 H65 F70 H144 T146 P155 A156
Gene Ontology
Molecular Function
GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Biological Process
GO:0009214 cyclic nucleotide catabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wdf, PDBe:4wdf, PDBj:4wdf
PDBsum4wdf
PubMed26563764
UniProtP16330|CN37_MOUSE 2',3'-cyclic-nucleotide 3'-phosphodiesterase (Gene Name=Cnp)

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