Structure of PDB 4wab Chain A

Receptor sequence
>4wabA (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
SPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYC
RSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVG
RVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHFLPAALRA
ALLGRLRTLRP
3D structure
PDB4wab Fast native-SAD phasing for routine macromolecular structure determination.
ChainA
Resolution2.704 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.-
2.5.1.-
2.5.1.18: glutathione transferase.
4.4.1.20: leukotriene-C4 synthase.
5.3.99.3: prostaglandin-E synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A R73 N74 E77 H113 Y117 R126 S127 Y130 R64 N65 E68 H104 Y108 R117 S118 Y121
BS02 LVJ A P124 S127 T131 L132 P115 S118 T122 L123
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0004667 prostaglandin-D synthase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
GO:0016853 isomerase activity
GO:0043295 glutathione binding
GO:0050220 prostaglandin-E synthase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006693 prostaglandin metabolic process
GO:0007165 signal transduction
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0019233 sensory perception of pain
GO:0031620 regulation of fever generation
GO:0032308 positive regulation of prostaglandin secretion
GO:0050727 regulation of inflammatory response
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wab, PDBe:4wab, PDBj:4wab
PDBsum4wab
PubMed25506719
UniProtO14684|PTGES_HUMAN Prostaglandin E synthase (Gene Name=PTGES);
Q16873|LTC4S_HUMAN Leukotriene C4 synthase (Gene Name=LTC4S)

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