Structure of PDB 4wa9 Chain A

Receptor sequence
>4wa9A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKEIKHPNLVQLLGVC
TREPIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN
FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM
ERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD
3D structure
PDB4wa9 Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D105 A107 R109 N110 D123 P144
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AXI A L248 Y253 A269 K271 F317 M318 T319 G321 L370 A380 F382 L13 Y18 A34 K36 F59 M60 T61 G63 L112 A122 F124 MOAD: Ki=3800pM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4wa9, PDBe:4wa9, PDBj:4wa9
PDBsum4wa9
PubMed25686603
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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